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Cognisom
Pioneering multi-scale cellular digital twins to understand and simulate the foundational building blocks of life — from protein folding to whole-cell dynamics.
Cognisom is a multi-year research program building cellular digital twins — computational models of cells fine-grained enough to simulate metabolic, regulatory, and signalling dynamics together.
The premise is straightforward: most biological reasoning still happens at the level of individual pathways. Cognisom asks what becomes possible when those pathways are simulated in concert, at the scale of a whole cell, with enough fidelity to predict the response to a perturbation before any physical experiment is run.
The program is computationally expensive, deliberately reproducible, and committed to releasing both the simulation code and the trained models on an open-access basis. Where industry partnerships are appropriate, the foundation retains derivative-rights to all methods.
What the program is asking.
01
How accurately can a whole-cell simulation predict drug response in non-cancer cell lines?
02
What scale of simulation is required to recover known regulatory motifs from first principles?
03
Where do current cellular models silently break down — and how do we instrument those failure modes?
The other programs.
Proposals welcome.
The Foundation accepts grant proposals, partnership inquiries, and fellowship applications from researchers whose work intersects with this program.